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Article

Clinical implication and usefulness of de novo EGFR T790M mutation in lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutation.

Cancer biology & therapy - 2 Aug 2020

Lee Sang Hoon, Kim Eun Young, Kim Arum, Chang Yoon Soo

Abstract excerpt

In total, 102 cases diagnosed as lung adenocarcinoma with EGFR-tyrosine kinase inhibitor (TKI) sensitizing mutations (mEGFR) and had been treated with 1st ~ 2nd generation EGFR-TKI alone were enrolled for this study. De novo T790 M status was tested using the tissues at the initial diagnosis and positivity was defined as the ratio of T790 M/wild-type copies over 0.00294 by ddPCR. Seventy patients (68.6%) harbored...

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PMID: 32543264
DOI: 10.1080/15384047.2020.1776579
PMCID: PMC7515544

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