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Article

The efficacy of T790M mutation testing in liquid biopsy-Real clinic data.

PloS one - 1 Jan 2022

Krawczyk Paweł, Grzycka-Kowalczyk Luiza, Błach Justyna, Reszka Katarzyna, Chmielewska Izabela, Kieszko Robert, Wójcik-Superczyńska Magdalena, Szczyrek Michał, Jankowski Tomasz, Milanowski Janusz

Abstract excerpt

Osimertnib is still widely used in the treatment of NSCLC patients who have previously received erlotinib, gefitinib or afatinib and have developed resistance to these drugs mediated by the T790M mutation in exon 20 of EGFR gene. We assessed the results of T790M mutation testing in liquid biopsy by Entrogen test and real-time PCR technique in routine clinical practice. Analysis was conducted in 73 plasma samples...

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Adenocarcinoma of Lung
Drug Resistance, Neoplasm
ErbB Receptors
Liquid Biopsy
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase Inhibitors

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PMID: 35522668
DOI: 10.1371/journal.pone.0267846
PMCID: PMC9075651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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