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Article

Usefulness of plasma HGF level for monitoring acquired resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer.

Oncology reports - 1 Jan 2015

Umeguchi Hitomi, Sueoka-Aragane Naoko, Kobayashi Naomi, Nakamura Tomomi, Sato Akemi, Takeda Yuji, Hayashi Shinichiro, Sueoka Eisaburo, Kimura Shinya

Abstract excerpt

Monitoring of molecular markers is indispensable for deciding subsequent treatment after acquired resistance to molecular-targeted therapy. According to results using re-biopsy, EGFR T790M mutation and overexpression of hepatocyte growth factor (HGF) are major mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). The aim of the present study was to assess...

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Source

Identifiers

PMID: 25338771
DOI: 10.3892/or.2014.3560

Genes

HGF
EGFR
MBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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