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Article

Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation.

Glia - 1 Mar 2016

Ossola Bernardino, Zhao Chao, Compston Alastair, Pluchino Stefano, Franklin Robin J M, Spillantini Maria Grazia

Abstract excerpt

Oligodendrocyte progenitor cell (OPC) differentiation is an important therapeutic target to promote remyelination in multiple sclerosis (MS). We previously reported hyperphosphorylated and aggregated microtubule-associated protein tau in MS lesions, suggesting its involvement in axonal degeneration. However, the influence of pathological tau-induced axonal damage on the potential for remyelination is unknown....

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Identifiers

PMID: 26576485
DOI: 10.1002/glia.22940
PMCID: PMC5132073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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