Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas.

Hypertension (Dallas, Tex. : 1979) - 1 Jan 2016

Williams Tracy Ann, Peitzsch Mirko, Dietz Anna S, Dekkers Tanja, Bidlingmaier Martin, Riester Anna, Treitl Marcus, Rhayem Yara, Beuschlein Felix, Lenders Jacques W M, Deinum Jaap, Eisenhofer Graeme, Reincke Martin

Abstract excerpt

Primary aldosteronism comprises 2 main subtypes: unilateral aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia. Somatic KCNJ5 mutations are found in APA at a prevalence of around 40% that drive and sustain aldosterone excess. Somatic APA mutations have been described in other genes (CACNA1D, ATP1A1, and ATP2B3) albeit at a lower frequency. Our objective was to identify genotype-specific steroid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Cortex Neoplasms
Share to Adrenocortical Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldosterone

Share to Chromatography, Liquid

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Share to Hydrocortisone

Share to Plasma Membrane Calcium-Transporting ATPases

Share to Sodium-Potassium-Exchanging ATPase

Source

Identifiers

PMID: 26573708
DOI: 10.1161/HYPERTENSIONAHA.115.06186

Genes

KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas.PMID 26573708Read ↗

Primary aldosteronism diagnostics: KCNJ5 mutations and hybrid steroid synthesis in aldosterone-producing adenomasSemantic proximity Read ↗

Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of primary aldosteronism by adrenal vein sampling.Semantic proximity Read ↗

Somatic mutations in adrenals from patients with primary aldosteronism not cured after adrenalectomy suggest common pathogenic mechanisms between unilateral and bilateral disease.Semantic proximity Read ↗

Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma.Semantic proximity Read ↗

GENETICS IN ENDOCRINOLOGY: The expanding genetic horizon of primary aldosteronism.Semantic proximity Read ↗

Update on the Genetics of Primary Aldosteronism and Aldosterone-Producing Adenomas.Semantic proximity Read ↗

Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype.Semantic proximity Read ↗

Clinical Translationality of KCNJ5 Mutation in Aldosterone Producing Adenoma.Semantic proximity Read ↗

GENETICS IN ENDOCRINOLOGY: Impact of race and sex on genetic causes of aldosterone-producing adenomasSemantic proximity Read ↗

Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.Semantic proximity Read ↗

Genetics and Primary Aldosteronism: Disease Phenotype and Demographic Implications for Hypertension.Semantic proximity Read ↗

Urine steroid metabolomics as a diagnostic tool in primary aldosteronism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.