GENETICS IN ENDOCRINOLOGY: The expanding genetic horizon of primary aldosteronism.

doi:10.1530/EJE-17-0946

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Article

GENETICS IN ENDOCRINOLOGY: The expanding genetic horizon of primary aldosteronism.

European journal of endocrinology - 1 Mar 2018

Monticone Silvia, Buffolo Fabrizio, Tetti Martina, Veglio Franco, Pasini Barbara, Mulatero Paolo

Abstract excerpt

Aldosterone is the main mineralocorticoid hormone in humans and plays a key role in maintaining water and electrolyte homeostasis. Primary aldosteronism (PA), characterized by autonomous aldosterone overproduction by the adrenal glands, affects 6% of the general hypertensive population and can be either sporadic or familial. Aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH) are the two...

Topics

Aldosterone
Calcium Channels, L-Type
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Genetic Variation
Humans
Hyperaldosteronism
Plasma Membrane Calcium-Transporting ATPases
Sodium-Potassium-Exchanging ATPase

Source

Open in PubMed

Identifiers

PMID: 29348113
DOI: 10.1530/EJE-17-0946

Genes

KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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