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Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations

13 Aug 2019

Abstract excerpt

Helicobacter pylori plays an essential role in the pathogenesis of gastritis, peptic ulcer disease, and gastric cancer. The serine protease HtrA, an important secreted virulence factor, disrupts the gastric epithelium, which enables H. pylori to transmigrate across the epithelium and inject the oncogenic CagA protein into host cells. The function of periplasmic HtrA for the H. pylori cell is unknown, mainly due...

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PMID: 31409845
DOI: 10.1038/s41598-019-48030-6

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