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Article

Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.

Cardiovascular research - 1 Dec 2012

d'Uscio Livius V, Das Pritam, Santhanam Anantha V R, He Tongrong, Younkin Steven G, Katusic Zvonimir S

Abstract excerpt

AIMS: Existing evidence suggests that amyloid-β precursor protein (APP) causes endothelial dysfunction and contributes to pathogenesis of atherosclerosis. In the present study, experiments were designed to: (1) determine the mechanisms underlying endothelial dysfunction and (2) define the effects of peroxisome proliferator-activated receptor delta (PPARδ) ligand on endothelial function in transgenic Tg2576 mice...

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Source

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Identifiers

PMID: 22886847
DOI: 10.1093/cvr/cvs266
PMCID: PMC3500044

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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