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Article

FasL expression in cardiomyocytes activates the ERK1/2 pathway, leading to dilated cardiomyopathy and advanced heart failure.

Clinical science (London, England : 1979) - 1 Feb 2016

Huby Anne-Cecile, Turdi Subat, James Jeanne, Towbin Jeffrey A, Purevjav Enkhsaikhan

Abstract excerpt

Increase in the apoptotic molecule Fas ligand (FasL) in serum and cardiomyocytes has been shown to be associated with progressive dilated cardiomyopathy (DCM) and congestive heart failure (CHF) in humans. However, the underlying mechanism(s) of FasL-related deterioration of heart function remain obscure. The aim of the present study is to determine roles of myocardial FasL in the activation of alternative...

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Source

Identifiers

PMID: 26566650
DOI: 10.1042/CS20150624

Genes

FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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