Article
A Direct Test of Selection in Cell Populations Using the Diversity in Gene Expression within Tumors.
Molecular biology and evolution - 1 Jul 2017
Li Chunyan, Hou Yali, Xu Jin, Zhang Aiqun, Liu Zhenzhen, Qi Furong, Yang Zuyu, Chen Ke, Liu Sixue, Huang Huanwei, Wang Qianfei, Dong Jiahong, Wu Chung-I, Lu Xuemei
Abstract excerpt
Although intratumor diversity driven by selection has been the prevailing view in cancer biology, recent population genetic analyses have been unable to reject the neutral interpretation. As the power to reject neutrality in tumors is often low, it will be desirable to have an alternative means to test selection directly. Here, we utilize gene expression data as a surrogate for functional significance in intra-...
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