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Article

Platelet response to a small molecule inhibitor of α2β1 integrin is associated with ITGA2 C807T dimorphism.

Platelets - 1 Jun 2016

Nissinen Liisa, Rappu Pekka, Ollikka Pauli, Nieminen Jonna, Marjamäki Anne, Heino Jyrki

Abstract excerpt

High expression of the collagen receptor, α2β1 integrin, on platelets of ITGA2 807T-allele carriers has been identified as a risk factor for thromboembolic conditions, and α2β1 inhibitors are considered to be potential therapeutic agents. In 59 genotyped individuals, we measured α2 expression levels on platelets and analyzed platelet adhesion to collagen under flow conditions. A sulfonamide-type small-molecule...

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Source

Identifiers

PMID: 26556301
DOI: 10.3109/09537104.2015.1095877

Genes

ITGA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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