Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system.

doi:10.3324/haematol.2011.056556

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system.

Haematologica - 1 May 2012

Kunicki Thomas J, Williams Shirley A, Diaz Daniel, Farndale Richard W, Nugent Diane J

Abstract excerpt

A single nucleotide polymorphism in the integrin α2 gene ITGA2 (rs1801106; G1600A) creates the non-conservative amino acid substitution E534K, the basis of the human platelet alloantigen system HPA-5. Yet HPA-5 alleles do not influence binding of α2β1 to its primary ligand collagen I, and the effect of HPA-5 on platelet function has not been determined. We used a direct platelet adhesion assay to evaluate whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Human Platelet

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blood Platelets

Share to Collagen Type I

Share to Decorin

Share to Integrin alpha2

Share to Platelet Adhesiveness

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22133774
DOI: 10.3324/haematol.2011.056556
PMCID: PMC3342970

Genes

ITGA2

Variants

rs1801106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system.PMID 22133774Read ↗

Adhesive and signaling properties of a naturally occurring allele of glycoprotein IIIa with an amino acid substitution within the ligand binding domain-the Pena/Penb platelet alloantigenic epitopes.Semantic proximity Read ↗

Platelet response to a small molecule inhibitor of α2β1 integrin is associated with ITGA2 C807T dimorphism.Semantic proximity Read ↗

A Point Mutation Thr799Met on the 2 Integrin Leads to the Formation of New Human Platelet Alloantigen Sita and Affects Collagen-Induced AggregationSemantic proximity Read ↗

High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1)Semantic proximity Read ↗

Analysis of platelet glycoprotein Ia (alpha2 integrin) allele frequencies in three North American populations reveals genetic association between nucleotide 807C/T and amino acid 505 Glu/Lys (HPA-5) dimorphisms.Semantic proximity Read ↗

Three novel beta3 domain-deletion peptides for the sensitive and specific detection of HPA-4 and six low frequency beta3-HPA antibodies.Semantic proximity Read ↗

Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density.Semantic proximity Read ↗

HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.Semantic proximity Read ↗

Rapid genotyping of the five major platelet alloantigens by reverse dot-blot hybridization.Semantic proximity Read ↗

A functional platelet fibrinogen receptor with a deletion in the cysteine-rich repeat region of the beta(3) integrin: the Oe(a) alloantigen in neonatal alloimmune thrombocytopenia.Semantic proximity Read ↗

A novel isoform of platelet glycoprotein Ib alpha is prevalent in African Americans.Semantic proximity Read ↗

Evidence for the Specificity for Platelet HPA-1a Alloepitope and the Presenting HLA-DR52a of Diverse Antigen-Specific Helper T Cell Clones from Alloimmunized MothersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.