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Article

Homozygosity for 807 T polymorphism in alpha(2) subunit of platelet alpha(2)beta(1) is associated with increased risk of cardiovascular mortality in high-risk women.

Circulation - 3 Oct 2000

Roest M, Banga J D, Grobbee D E, de Groot P G, Sixma J J, Tempelman M J, van der Schouw Y T

Abstract excerpt

BACKGROUND: Platelet adhesion to collagen is the initial step in both hemostasis and thrombosis; this adhesion is mediated by alpha(2)beta(1) on the surface of platelet membranes. An 807 C to T single nucleotide exchange polymorphism close to the gene coding for the alpha(2) subunit of alpha(2)beta(1) is associated with the density of alpha(2)beta(1) on the platelet membrane. METHODS AND RESULTS: We studied the...

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PMID: 11015342
DOI: 10.1161/01.cir.102.14.1645

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