Article
Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density.
Blood - 1 Oct 1998
Kritzik M, Savage B, Nugent D J, Santoso S, Ruggeri Z M, Kunicki T J
Abstract excerpt
Three allelic differences in the alpha2 gene are associated with expression levels of the alpha2beta1 integrin on the platelet surface. We have previously defined two linked silent polymorphisms in the alpha2 gene coding region at nucleotides 807 (C or T) and 873 (G or A). We have now identified...
Topics
- Alleles
- Antigens, CD
- Codon
- Collagen
- DNA Mutational Analysis
- Humans
- Integrin alpha2
- Integrins
- Introns
- Isoantigens
- Platelet Adhesiveness
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Receptors, Collagen
- Stress, Mechanical
- Structure-Activity Relationship