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Article

Model organisms in POLG-related disorders: insights from yeast to multicellular systems.

Cell death & disease - 26 Dec 2025

Brañas Casas Raquel, Risato Giovanni, Zuppardo Alessandro, Viscomi Carlo, Argenton Francesco, Doimo Mara, Facchinello Nicola, Tiso Natascia

Abstract excerpt

Mitochondrial genetic diseases are complex disorders that impair cellular energy production, leading to diverse clinical manifestations across multiple organ systems. These diseases arise from mutations in either mitochondrial DNA or nuclear DNA. Among nuclear DNA-related cases, mutations in POLG and POLG2, which encode subunits of mitochondrial DNA polymerase γ, are particularly significant, causing conditions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41453949
DOI: 10.1038/s41419-025-08366-6
PMCID: PMC12847702

Genes

POLG
POLG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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