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Article

Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.

Journal of bacteriology - 1 Feb 2016

Hou Jing, Zheng Heping, Chruszcz Maksymilian, Zimmerman Matthew D, Shumilin Igor A, Osinski Tomasz, Demas Matt, Grimshaw Sarah, Minor Wladek

Abstract excerpt

UNLABELLED: β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. The activation of the enzyme is usually linked to the formation of a catalytic triad and cofactor binding, and crystal structures of FabG from different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26553852
DOI: 10.1128/JB.00360-15
PMCID: PMC4719456

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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