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Article

Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change.

Proteins - 15 Aug 2005

Cohen-Gonsaud Martin, Ducasse-Cabanot Stéphanie, Quemard Annaïk, Labesse Gilles

Abstract excerpt

The protein MabA of Mycobacterium tuberculosis is a beta-ketoacyl reductase (KAR) and catalyses one of the four steps of the fatty acid elongation system FAS-II. The crystal structures of different KARs revealed a significant rearrangements of the active site between a "closed" inactive conformat...

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Identifiers

PMID: 15977159
DOI: 10.1002/prot.20494

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15977159-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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