Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

9 Nov 2015

Abstract excerpt

BACKGROUND AND PURPOSE: The selection of the most suitable animal species and subsequent translation of the concentration-effect relationship to humans are critical steps for accurate assessment of the pro-arrhythmic risk of candidate molecules. The objective of this investigation was to assess quantitatively the differences in the QTc prolonging effects of moxifloxacin between cynomolgus monkeys, dogs and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Ion channel regulation and function
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26553352
DOI: 10.1007/s11095-015-1760-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and HumansPMID 26553352Read ↗

Preclinical QT safety assessment: Cross-species comparisons and human translation from an industry consortiumSemantic proximity Read ↗

In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitorSemantic proximity Read ↗

Risk assessment of drug-induced Long QT Syndrome for some COVID-19 repurposed drugsSemantic proximity Read ↗

Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learningSemantic proximity Read ↗

Patient variation in veterinary medicine--part II--influence of physiological variables.Semantic proximity Read ↗

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.Semantic proximity Read ↗

Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.Semantic proximity Read ↗

Parametric imaging of P-glycoprotein function at the blood-brain barrier using kE,brain-maps generated from [11C]metoclopramide PET data in rats, nonhuman primates and humansSemantic proximity Read ↗

Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19.Semantic proximity Read ↗

Impact of ABCB1 allelic variants on QTc interval prolongation.Semantic proximity Read ↗

Thorough QT study with recommended and supratherapeutic doses of tolterodine.Semantic proximity Read ↗

QT and QTc interval with standard and supratherapeutic doses of darifenacin, a muscarinic M3 selective receptor antagonist for the treatment of overactive bladder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.