Article
Thorough QT study with recommended and supratherapeutic doses of tolterodine.
Clinical pharmacology and therapeutics - 1 Mar 2007
Malhotra B K, Glue P, Sweeney K, Anziano R, Mancuso J, Wicker P
Abstract excerpt
The objective of our study was to determine the QTc effects of tolterodine. A crossover-design thorough QT study of recommended (2 mg twice daily) and supratherapeutic (4 mg twice daily) doses of tolterodine, moxifloxacin (400 mg once daily), and placebo was performed. Electrocardiograms (ECGs) and pharmacokinetic samples were obtained on days 1-4; time-matched baseline ECGs were taken on day 0. Mean...
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