Article
Impact of ABCB1 allelic variants on QTc interval prolongation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2011
Sissung Tristan M, Gardner Erin R, Piekarz Richard L, Howden Reuben, Chen Xiaohong, Woo Sukyung, Franke Ryan, Clark James A, Miller-DeGraff Laura, Steinberg Seth M, Venzon David, Liewehr David, Kleeberger Steven R, Bates Susan E, Price Douglas K, Rosing Douglas R, Cabell Christopher, Sparreboom Alex, Figg William D
Abstract excerpt
PURPOSE: Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood-tissue barriers (i.e., blood-brain and blood-nerve), its participation in a putative blood-heart barrier has been poorly explored. ABCB1 could decrease the intracardiac concentrations of drugs that cause QT prolongation and cardiotoxicity. EXPERIMENTAL DESIGN: ABCB1-related romidepsin transport kinetics were explored...
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