Article

Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning

2020-10-27

Abstract excerpt

Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of hERG channel block in vitro and QT interval prolongation in vivo for all new therapeutic compounds. Unfortunately, these have proven to be poor predictors of torsadogenic risk, and are likely to have prevented safe compounds from reac...

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Literature Corpus work: 75f8bac9-02b9-55f3-b9bb-b000c6464faa
DOI: 10.1101/2020.10.26.352740

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