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Article

Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring.

Biochemical and biophysical research communications - 25 Dec 2015

Mountassif Driss, Fabre Lucien, Zaid Younes, Halawani Dalia, Rouiller Isabelle

Abstract excerpt

Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting brain, muscle and bone tissue. Previous studies have demonstrated the role of VCP mutations in altering the ATPase activity of the D2 ring; however the structural consequences of...

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Source

Identifiers

PMID: 26549226
DOI: 10.1016/j.bbrc.2015.11.003

Genes

VCP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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