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<i>In silico</i> Study of the Uncertainly Significant <i>VCP</i> Variants reveal major Structural, Functional fluctuations leading to potential Disease-Based Associations

2023-11-05

Abstract excerpt

Valosin containing protein is involved in a plethora of crucial functions from proteostasis, stress granule clearance to genome maintenance and ubiquitination. Hence, mutations in VCP can lead to a plethora of fatal diseases like Amyotrophic Lateral Sclerosis, Inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1, Spastic paraplegia, Charcot-Marie-Tooth disease type 2Y, Dementia, a...

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Literature Corpus work
3b72e63f-7743-5cdc-874a-1b339b9c1c0c
DOI
10.1101/2023.11.04.565542
Open publication

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<i>In silico</i> Study of the Uncertainly Significant <i>VCP</i> Variants reveal major Structural, Functional fluctuations leading to potential Disease-Based AssociationsDOI 10.1101/2023.11.04.565542
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