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Article

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.

The international journal of biochemistry & cell biology - 1 Apr 2013

Erzurumlu Yalcin, Kose Fadime Aydin, Gozen Oguz, Gozuacik Devrim, Toth Eric A, Ballar Petek

Abstract excerpt

p97/VCP is a hexameric AAA type ATPase that functions in a variety of cellular processes such as endoplasmic reticulum associated degradation (ERAD), organelle biogenesis, autophagy and cell-cycle regulation. Inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (IBMPFD) is an autosomal dominant disorder which has been attributed to mutations in p97/VCP. Several missense...

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Source

Identifiers

PMID: 23333620
DOI: 10.1016/j.biocel.2013.01.006

Genes

VCP
VIM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.PMID 23333620Read ↗

IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.Semantic proximity Read ↗

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Recent advances in p97/VCP/Cdc48 cellular functions.Semantic proximity Read ↗

Structural and functional deviations in disease-associated p97 mutants.Semantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97 Oligomerization.Semantic proximity Read ↗

Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy.Semantic proximity Read ↗

Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.Semantic proximity Read ↗

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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.Semantic proximity Read ↗

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and boneSemantic proximity Read ↗

Valosin-containing protein gene mutations: clinical and neuropathologic features.Semantic proximity Read ↗

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