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Article

Muscle tissue engineering and regeneration through epigenetic reprogramming and scaffold manipulation.

Scientific reports - 9 Nov 2015

Tan S J, Fang J Y, Wu Y, Yang Z, Liang G, Han B

Abstract excerpt

Efficiency of cell-based tissue engineering and regenerative medicine has been limited by inadequate cellular responses to injury because of aging and poor controllability of cellular interactions. Since cell progression is under a tight epigenetic regulation, epigenetic modulators such as 5-azacytidine (5-Aza-CR) have been utilized to facilitate reprogramming and development of somatic cells in 2-dimensional...

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Identifiers

PMID: 26548559
DOI: 10.1038/srep16333
PMCID: PMC4637833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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