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Article

Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell-based cartilage tissue engineering.

Science advances - 1 May 2020

Lee Junmin, Jeon Oju, Kong Ming, Abdeen Amr A, Shin Jung-Youn, Lee Ha Neul, Lee Yu Bin, Sun Wujin, Bandaru Praveen, Alt Daniel S, Lee KangJu, Kim Han-Jun, Lee Sang Jin, Chaterji Somali, Shin Su Ryon, Alsberg Eben, Khademhosseini Ali

Abstract excerpt

Despite great progress in biomaterial design strategies for replacing damaged articular cartilage, prevention of stem cell-derived chondrocyte hypertrophy and resulting inferior tissue formation is still a critical challenge. Here, by using engineered biomaterials and a high-throughput system for screening of combinatorial cues in cartilage microenvironments, we demonstrate that biomaterial cross-linking density...

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Topics

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Share to Biocompatible Materials
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Mechanotransduction, Cellular

Share to Mesenchymal Stem Cells

Share to Phenotype

Share to Stem Cells

Share to Tissue Engineering

Source

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Identifiers

PMID: 32494742
DOI: 10.1126/sciadv.aaz5913
PMCID: PMC7244269

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