Article

Compressive forces induce epigenetic activation of aged human dermal fibroblasts through ERK signaling pathway

2024-11-05

Abstract excerpt

Age-related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging. While these changes result in altered mechanotransduction, the epigenetic basis of rejuvenating aging cells remains a significant challenge. This study investigates the effects of compressive forces on nuclear mechanotransduction and epigenetic rejuvenation in aged HDFs. Using a compressive force application...

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Literature Corpus work: 855ae684-fbec-5ad8-9d29-16226e6a57ab
DOI: 10.1101/2024.11.04.621794

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