Article
HLA Haplotype Validator for quality assessments of HLA typing.
Human immunology - 1 Mar 2016
Osoegawa Kazutoyo, Mack Steven J, Udell Julia, Noonan David A, Ozanne Steven, Trachtenberg Elizabeth, Prestegaard Matthew
Abstract excerpt
HLA alleles are observed in specific haplotypes, due to Linkage Disequilibrium (LD) between particular alleles. Haplotype frequencies for alleles in strong LD have been established for specific ethnic groups and racial categories. Application of high-resolution HLA typing using Next Generation Sequencing (NGS) is becoming a common practice in research and clinical laboratory settings. HLA typing errors using NGS...
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