Article
Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes.
The Journal of biological chemistry - 1 Jan 2016
Kuruganti Srilalitha, Miersch Shane, Deshpande Ashlesha, Speir Jeffrey A, Harris Bethany D, Schriewer Jill M, Buller R Mark L, Sidhu Sachdev S, Walter Mark R
Abstract excerpt
Exogenous cytokine therapy can induce systemic toxicity, which might be prevented by activating endogenously produced cytokines in local cell niches. Here we developed antibody-based activators of cytokine signaling (AcCS), which recognize cytokines only when they are bound to their cell surface receptors. AcCS were developed for type I interferons (IFNs), which induce cellular activities by binding to cell...
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