HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer.

doi:10.1158/1078-0432.CCR-15-2044

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Article

HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2016

Xu Chun-Fang, Johnson Toby, Wang Xiaojing, Carpenter Chris, Graves Alan P, Warren Liling, Xue Zhengyu, King Karen S, Fraser Dana J, Stinnett Sandy, Briley Linda P, Mitrica Ionel, Spraggs Colin F, Nelson Matthew R, Tada Hiroomi, du Bois Andreas, Powles Thomas, Kaplowitz Neil, Pandite Lini N

Abstract excerpt

PURPOSE: Pazopanib is an effective treatment for advanced renal cell carcinoma and soft-tissue sarcoma. Transaminase elevations have been commonly observed in pazopanib-treated patients. We conducted pharmacogenetic analyses to explore mechanistic insight into pazopanib-induced liver injury. EXPERIMENTAL DESIGN: The discovery analysis tested association between four-digit HLA alleles and alanine aminotransferase...

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PMID: 26546620
DOI: 10.1158/1078-0432.CCR-15-2044
PMCID: PMC7444994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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