Article
Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 2014
Schaid Daniel J, Spraggs Colin F, McDonnell Shannon K, Parham Laura R, Cox Charles J, Ejlertsen Bent, Finkelstein Dianne M, Rappold Erica, Curran Joan, Cardon Lon R, Goss Paul E
Abstract excerpt
PURPOSE: Liver injury is a serious adverse event leading to permanent discontinuation of lapatinib in affected patients. This study aimed to validate previously associated major histocompatibility complex (MHC) variants as predictors of risk of liver injury by using a large, randomized, placebo-controlled trial of lapatinib in human epidermal growth factor receptor 2-positive, early-stage breast cancer (Tykerb...
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