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Article

Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma.

Journal of hepatology - 1 Jun 2011

Xu Chun-Fang, Reck Brian H, Goodman Vicki L, Xue Zhengyu, Huang Lingkang, Barnes Michael R, Koshy Beena, Spraggs Colin F, Mooser Vincent E, Cardon Lon R, Pandite Lini N

Abstract excerpt

BACKGROUND & AIMS: Pazopanib has demonstrated clinical benefit in patients with advanced renal cell carcinoma (RCC) and is generally well tolerated. However, transaminase elevations have commonly been observed. This 2-stage study sought to identify genetic determinants of alanine transaminase (AL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21145803
DOI: 10.1016/j.jhep.2010.09.028

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21145803-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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