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Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer

25 Apr 2020

Abstract excerpt

The term aggressive variant prostate cancer (AVPCa) refers to androgen receptor (AR)-independent anaplastic forms of prostate cancer (PCa), clinically characterized by a rapidly progressive disease course. This involves hormone refractoriness and metastasis in visceral sites. Morphologically, AVPCa is made up of solid sheets of cells devoid of pleomorphism, with round and enlarged nuclei with prominent nucleoli...

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PMID: 32344931
DOI: 10.3390/cells9051073

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