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Article

Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features

13 Dec 2011

Abstract excerpt

PURPOSE: Small-cell prostate carcinoma (SCPC) morphology predicts for a distinct clinical behavior, resistance to androgen ablation, and frequent but short responses to chemotherapy. We sought to develop model systems that reflect human SCPC and can improve our understanding of its biology. EXPERIMENTAL DESIGN: We developed a set of castration-resistant prostate carcinomas xenografts and examined their fidelity...

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PMID: 22156612
DOI: 10.1158/1078-0432.ccr-11-1867

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