Article

Integrating Aggressive Variant Prostate Cancer-Associated Tumor Suppressor Gene Status to Refine Prognosis and Predict Androgen-Receptor Pathway Inhibitors Response in Metastatic Hormone-Sensitive Prostate Cancer

2025-04-24

Abstract excerpt

<h4>Purpose: </h4> Alterations in Aggressive Variant Prostate Cancer-Associated Tumor Suppressor Genes (AVPC-TSG: TP53, RB1, PTEN) are related with androgen insensitivity and aggres-sive disease. However, their prognostic and predictive role in metastatic hor-mone-sensitive prostate cancer (mHSPC) is unclear. This single-center retrospective study assesses the value of AVPC-TSG alterations in re-fining prognosis a...

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Literature Corpus work: 045e5661-a6c2-5da7-ad07-bd79a0559b90
DOI: 10.20944/preprints202504.2046.v1

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