Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of CD40 and CD40L in bone mineral density and in osteoporosis risk: A genetic and functional study.

Bone - 1 Feb 2016

Panach Layla, Pineda Begoña, Mifsut Damián, Tarín Juan J, Cano Antonio, García-Pérez Miguel Ángel

Abstract excerpt

Compelling data are revealing that the CD40/CD40L system is involved in bone metabolism. Furthermore, we have previously demonstrated that polymorphisms in both genes are associated with bone phenotypes. The aim of this study is to further characterize this association and to identify the causal functional mechanism. We conducted an association study of BMD with 15 SNPs in CD40/CD40L genes in a population of 779...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Density
Share to CD40 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD40 Ligand

Share to CpG Islands

Share to Inheritance Patterns

Share to Osteoporosis

Share to Osteoprotegerin

Source

Identifiers

PMID: 26545336
DOI: 10.1016/j.bone.2015.11.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of CD40 and CD40L in bone mineral density and in osteoporosis risk: A genetic and functional study.PMID 26545336Read ↗

Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.Semantic proximity Read ↗

A C >T polymorphism located at position -1 of the Kozak sequence of CD40 gene is associated with low bone mass in Spanish postmenopausal women.Semantic proximity Read ↗

Functional polymorphisms within the TNFRSF11B (osteoprotegerin) gene increase the risk for low bone mineral density.Semantic proximity Read ↗

A translational approach from an animal model identifies CD80 as a candidate gene for the study of bone phenotypes in postmenopausal women.Semantic proximity Read ↗

Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women.Semantic proximity Read ↗

Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients.Semantic proximity Read ↗

Association of the aromatase gene alleles with BMD: epidemiological and functional evidence.Semantic proximity Read ↗

Circulating amounts of osteoprotegerin and RANK ligand: Genetic influence and relationship with BMD assessed in female twinsSemantic proximity Read ↗

MS risk allele rs1883832T is associated with decreased mRNA expression of CD40.Semantic proximity Read ↗

CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico.Semantic proximity Read ↗

Polymorphisms in key bone modulator cytokines genes influence bisphosphonates therapy in postmenopausal women.Semantic proximity Read ↗

Genes influencing variation in serum osteocalcin concentrations are linked to markers on chromosomes 16q and 20q.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.