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Article

Genes influencing variation in serum osteocalcin concentrations are linked to markers on chromosomes 16q and 20q.

The Journal of clinical endocrinology and metabolism - 1 Apr 2000

Mitchell B D, Cole S A, Bauer R L, Iturria S J, Rodriguez E A, Blangero J, MacCluer J W, Hixson J E

Abstract excerpt

Osteocalcin (OC) is an important constituent of bone that is synthesized by osteoblasts. Serum levels of OC have been used as a biochemical marker of bone turnover. To identify the genes influencing variation in serum OC levels, we conducted a genome-wide scan in 429 individuals comprising 10 large multigenerational families. OC levels were measured by immunoassay, and genetic markers were typed at approximately...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10770166
DOI: 10.1210/jcem.85.4.6571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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