Article
Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 May 2011
Pineda B, Tarín J J, Hermenegildo C, Laporta P, Cano A, García-Pérez M Á
Abstract excerpt
SUMMARY: We have analysed the association of single-nucleotide polymorphisms (SNPs) in CD40 and CD40L genes with bone mineral density (BMD) in our women. Results showed that women with TT genotype for rs1883832 (CD40) and for rs1126535 (CD40L) SNPs displayed reduced BMD and increased risk for osteopenia/osteoporosis. Our data notwithstanding, the results need to be replicated. INTRODUCTION: Recent data have...
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