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Article

Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients.

BioMed research international - 1 Jan 2014

Hein Alexander, Bayer Christian M, Schrauder Michael G, Häberle Lothar, Heusinger Katharina, Strick Reiner, Ruebner Matthias, Lux Michael P, Renner Stefan P, Schulz-Wendtland Rüdiger, Ekici Arif B, Hartmann Arndt, Beckmann Matthias W, Fasching Peter A

Abstract excerpt

The receptor activator of NF-κB (RANK) pathway is involved in bone health as well as breast cancer (BC) pathogenesis and progression. Whereas the therapeutic implication of this pathway is established for the treatment of osteoporosis and bone metastases, the application in adjuvant BC is currently investigated. As genetic variants in this pathway have been described to influence bone health, aim of this study...

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Identifiers

PMID: 24729980
DOI: 10.1155/2014/842452
PMCID: PMC3963378

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