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Article

A Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas

10 Jun 2021

Abstract excerpt

There are no effective strategies for the successful treatment of glioblastomas (GBM). Current therapeutic modalities effectively target bulk tumor cells but leave behind marginal GBM cells that escape from the surgical margins and radiotherapy field, exhibiting high migratory phenotype and resistance to all available anti-glioma therapies. Drug resistance is mostly driven by tumor cell plasticity: a concept...

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PMID: 34178638
DOI: 10.3389/fonc.2021.652133

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