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Article

Therapeutic Exploitation of Apoptosis and Autophagy for Glioblastoma

1 Jul 2010

Abstract excerpt

Induction of caspase-dependent apoptosis (type I cell death) is a major mechanism by which most chemotherapeutic drugs and radiation kill tumor cells. However, conventional cancer therapies fail to mediate their effects in a target-specific fashion. The extremely unfavorable prognosis for patients suffering from glioblastomas (GBMs) is strongly correlated to the intrinsic apoptosis resistance of GBM cells which...

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PMID: 20879985
DOI: 10.2174/1871520611009060438

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