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Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

1 Jan 2010

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers in man. Despite technological advances in surgical management, combined regimens of radiotherapy with new generation chemotherapy, the median survival for these patients is 14.6 months. This is largely due to a highly deregulated tumour genome with opportunistic deletion of tumour suppressor...

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PMID: 20515495
DOI: 10.1186/1476-4598-9-135

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