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Article

Synthetic Tet-inducible artificial microRNAs targeting β-catenin or HIF-1α inhibit malignant phenotypes of bladder cancer cells T24 and 5637.

Scientific reports - 6 Nov 2015

Zhan Yonghao, Liu Yuchen, Lin Junhao, Fu Xing, Zhuang Chengle, Liu Li, Xu Wen, Li Jianfa, Chen Mingwei, Zhao Guoping, Huang Weiren, Cai Zhiming

Abstract excerpt

Ribonucleic acid interference (RNAi) based on microRNA (miRNA) may provide efficient and safe therapeutic opportunities. However, natural microRNAs can not easily be regulated and usually cause few phenotypic changes. Using the engineering principles of synthetic biology, we provided a novel and standard platform for the generation of tetracycline (Tet)-inducible vectors that express artificial microRNAs in a...

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Source

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Identifiers

PMID: 26541358
DOI: 10.1038/srep16177
PMCID: PMC4635424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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