Article
Synthetic Tet-inducible small hairpin RNAs targeting hTERT or Bcl-2 inhibit malignant phenotypes of bladder cancer T24 and 5637 cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Mar 2016
Lin Junhao, Liu Yuchen, Zhan Yonghao, Zhuang Chengle, Liu Li, Fu Xing, Xu Wen, Li Jianfa, Chen Mingwei, Cai Zhiming, Huang Weiren
Abstract excerpt
Small hairpin RNA (shRNA) can inhibit the malignant phenotypes of tumor cell through ribonucleic acid interference (RNAi). However, it is hardly to be regulated and it may induce few phenotypic changes. Here, we build a type of tetracycline (Tet)-inducible vectors which can achieve regulatable expression of shRNA in a time-dependent manner by using synthetic biology approach. In order to prove the effectiveness...
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