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Article

Synthetic artificial "long non-coding RNAs" targeting oncogenic microRNAs and transcriptional factors inhibit malignant phenotypes of bladder cancer cells.

Cancer letters - 28 May 2018

Xie Haibiao, Zhan Hengji, Gao Qunjun, Li Jianfa, Zhou Qun, Chen Zhicong, Liu Yuhan, Ding Mengting, Xiao Huizhong, Liu Yuchen, Huang Weiren, Cai Zhiming

Abstract excerpt

Both oncogenic transcription factors (TFs) and microRNAs (miRNAs) play important roles in human cancers, acting as transcriptional and post-transcriptional regulators, respectively. These phenomena raise questions about the ability of an artificial device to simultaneously regulate miRNAs and TFs. In this study, we aimed to construct artificial long non-coding RNAs, "alncRNAs", and to investigate their...

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PMID: 29501702
DOI: 10.1016/j.canlet.2018.02.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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