Article
Synthetic Bax-Anti Bcl2 combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer.
Journal of experimental & clinical cancer research : CR - 8 Jan 2016
Liu Li, Liu Yuchen, Zhang Tianbiao, Wu Hanwei, Lin Muqi, Wang Chaoliang, Zhan Yonghao, Zhou Qing, Qiao Baoping, Sun Xiaojuan, Zhang Qiaoxia, Guo Xiaoqiang, Zhao Guoping, Zhang Weixing, Huang Weiren
Abstract excerpt
BACKGROUND: The synthetic biology technology which enhances the specificity and efficacy of treatment is a novel try in biomedical therapy during recent years. A high frequency of somatic mutations was shown in the human telomerase reverse transcriptase (hTERT) promoter in bladder cancer, indicating that a mutational hTERT promoter might be a tumor-specific element for bladder cancer therapy. In our study, we...
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