Article
Pleiotropic Effects of Immune Responses Explain Variation in the Prevalence of Fibroproliferative Diseases.
PLoS genetics - 1 Nov 2015
Russell Shirley B, Smith Joan C, Huang Minjun, Trupin Joel S, Williams Scott M
Abstract excerpt
Many diseases are differentially distributed among human populations. Differential selection on genetic variants in ancestral environments that coincidentally predispose to disease can be an underlying cause of these unequal prevalence patterns. Selected genes may be pleiotropic, affecting multiple phenotypes and resulting in more than one disease or trait. Patterns of pleiotropy may be helpful in understanding...
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