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Article

Evolution of cytokine production capacity in ancient and modern European populations.

eLife - 7 Sept 2021

Domínguez-Andrés Jorge, Kuijpers Yunus, Bakker Olivier B, Jaeger Martin, Xu Cheng-Jian, Van der Meer Jos Wm, Jakobsson Mattias, Bertranpetit Jaume, Joosten Leo Ab, Li Yang, Netea Mihai G

Abstract excerpt

As our ancestors migrated throughout different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits that influence the genetic adaptation in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34488939
DOI: 10.7554/eLife.64971
PMCID: PMC8423439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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