Article
Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction.
Molecular & cellular proteomics : MCP - 1 Feb 2012
Wang YongQiang, Guan Shenheng, Acharya Poulomi, Liu Yi, Thirumaran Ranjit K, Brandman Relly, Schuetz Erin G, Burlingame Alma L, Correia Maria Almira
Abstract excerpt
CYP3A4, an integral endoplasmic reticulum (ER)-anchored protein, is the major human liver cytochrome P450 enzyme responsible for the disposition of over 50% of clinically relevant drugs. Alterations of its protein turnover can influence drug metabolism, drug-drug interactions, and the bioavailability of chemotherapeutic drugs. Such CYP3A4 turnover occurs via a classical ER-associated degradation (ERAD) process...
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