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Article

SHV-129: A Gateway to Global Suppressors in the SHV β-Lactamase Family?

Molecular biology and evolution - 1 Feb 2016

Winkler Marisa L, Bonomo Robert A

Abstract excerpt

Enzymes are continually evolving in response to environmental pressures. In order to increase enzyme fitness, amino acid substitutions can occur leading to a changing function or an increased stability. These evolutionary drivers determine the activity of an enzyme and its success in future generations in response to changing conditions such as environmental stressors or to improve physiological function allowing...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26531195
DOI: 10.1093/molbev/msv235
PMCID: PMC4909130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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